配方类型:

DRUGS

配方说明:

Tablets (Griseofulvin, 250 mg)

配方组成:

"Cab-O-Sil" M-7/1.50
Starch Paste (30% W/V)/1.67
"Veegum" F/8.33
"Emdex"/10.00
"Avicel" PH 101/19.16
Lactose/16.67
Griseofulvin (micronized)/41.67
Stearic Acid/1.00

配制方法:

Prepare a wet granulation of griseofulvin. Mix the griseofulvin, lactose, and starch paste and pass through a 14-mesh sieve. Dry the granules in a 60 C oven for 6 h. Collect granules passing through a 20-mesh sieve. Combine griseofulvin granules, "Veegum" F, "Emdex," and "Avicel" PH 101 and mix for 15 min. Add the stearic acid and "Cab-O-Sil" to the mixture and blend for an additional 10 min. Compress.
Mean Tablet Wt. (n=20)---597 mg Mean hardness---7 kg Friability---0.27% Disintegration Time (Purified water)---3 min