配方类型:

DRUGS

配方说明:

Tablets (Prednisone, 5 mg)

配方组成:

Dicalcium Phosphate Dihydrate/77.6
Magnesium Stearate/0.5
Tablet Wt./200 mg
Phenobarbitone/-
Relative Wt. Standard Deviation/0.65%
Ejection Force/160 N
Lactose (extra fine crystalline)/-
Crushing Strength (Schleuniger)/8.2 kg
Friability (Roche, 100 rotations)/0.1%
Disintegrating Time (USP XIX)/10 s
Disintegrating Time (without using discs)/9 s
"Primojel"/2.4
Microcrystalline Cellulose/17.0
Prednisone (micronized)/2.5
Colloidal Silica/-

配制方法:

Prepare by direct compression using an instrumented single punch tableting machine at a compression force of 20 kN. Tablet diameter: 7 mm for the prednisone tablets and 9 mm for the phenobarbitone tablets.
After storage of the tablets at extreme humid conditions, 8 weeks 20 C and 85% relative humidity, the disintegration time was 20 s for the prednisone tablets and 29 s for the phenobarbitone tablets.