配方类型:

COSMETICS AND DRUGS

配方说明:

Ointment Base (Anhydrous)

配方组成:

Coal tar, 3%; Zinc oxide, 25%; and Starch/25
Ethyl Aminobenzoate/5
Heat "Carbowax" polyethylene glycol 4000 with the 1,2,6-hexanetriol
on a water bath at 140-158'F (60-70'C). Add this melt to "Carbowax"
polyethylene glycol 400 at room temperature with vigorous stirring. Stir
occasionally until solidification takes place.
The melting point of this base is 125.1'F (51.7'C).
This modified ointment base has a good appearance, little tendency to
become granular, and is compatible with all important ointment
ingredients.
The solvent power of the 1,2,6-hexanetriol increases the compatibility
of "Carbowax" polyethylene glycols with drugs and improves the stability
of the ointments. The low melting point and high viscosity of the triol
lead to a softer preparation at all temperatures and prevent separation
or bleeding of the liquid components. The triol, on 90-day feeding
tests, is comparable to glycerol in toxicity. Patch tests have
demo

配制方法:

the tannic acid and coal tar ointments were stable but somewhat sticky. Their consistency was improved by increasing the proportion of "Carbowax" polyethylene glycol 400.
If more than 10 per cent of water is to be added to base No.4, the consistency will be improved by increasing the 4000 component or decreasing the 400 glycol.