配方类型:

DRUGS

配方说明:

Aspirin Tablet (Children's)

配方组成:

Sodium saccharin/7 g
Stearic acid/0.3
Flavor/q.s.
Mannitol granulation/99.1
10% Acacia solution/230 ml
Mannitol, USP (powdered)/1000 g
Starch/10.6
Aspirin (20-mesh)/81.0
Talc/8.0

配制方法:

Granulation of excipient: Granulate the mannitol and saccharin with the acacia solution, dry at 110'f and pass through a 20-mesh screen.
Preparation of aspirin mixture: Mix the aspirin with the dried mannitol granulation. Take extreme care to avoid moisture pick-up. Add the flavor to the starch, mixing thoroughly. Add the talc and stearic acid, screened to 100-mesh, to the flavor-starch mixture. Blend this combination of flavoring, starch, talc stearic acid with the mannitol-aspirin mixture.
Compression: compress using 11/32 inch standard concave punch to a hardness of 4-6 kg (Strong-Cobb-Arner tester).