配方类型:

DRUG PRODUCTS

配方说明:

Toothpaste

配方组成:

Glycerin/0.0-15.0
Add "Veegum" slowly to water, agitating continually until smooth.
Mix the sorbitol and glycerin together and use this to wet the sodium
CMC. Add B to A. Add C slowly with agitation. Add D and min. Add E
slowly with just enough mixing to obtain a smooth batch.
Aerosol package: concentrate 99%, propellant 12/114, 60/40 1%. This
formula should be packaged in a "Sepro" can and Precision Valve for
maximum evacuation of product from the can.
FORMULA No.
Water/28.0
Sweetener/0.1-0.2
Flavor/0.5-3.0
Sodium Benzoate/0.5
Binder/0.5-2.0
Therapeutic Ingredient/effective level
Preservative/effective level
Water/to 100.0
Flavor/0.5
Sodium Lauryl Sulfate/2.0
A: "Veegum"/2.0
Water/19.3
B: Sodium Carboxymethylcellulose of (high viscosity)/0.2
Sorbitol (70% sol'n)/15.0
Glycerin/15.0
C: Dicalcium Phosphate Dihydrate/45.0
D: Flavor/1.0
Glycerin/20.0
E: Sodium Lauryl Sulfate/2.0

配制方法:

Dissolve the sodium lauryl sulfate in 1/3 of the water. Mix the Sorbo, sodium saccharine and 6% Carbopol solution with the rest of the water. This will be a thin solution. Blend the two solutions carefully to avoid foaming. Slowly add the sodium hydroxide to neutralize the Carbopol 934 while gently stirring. The solution will become thick as the neutralization progresses. Slowly mix in the calcium phosphate. Stir until the particles are wetted out and all the lumps are broken up. Mix and deaerate the batch on conventional equipment. Add the flavoring during the last stages of milling to avoid evaporation loss. Tube the product.