配方类型:

SUSPENSIONS AND EMULSIONS

配方说明:

Triple-Sulfonamide Suspension

配方组成:

Propyl p-Hydroxy Benzoate/0.02 g
Sulfamerazine (USP)/3.33 g
Distilled Water/q.s. 100.00 cc
Sodium Citrate/1.00 g
Sulfamethazine (USP)/3.33 g
Sucrose/50.00 g
Sulfadiazine (USP)/3.33 g
Methyl p-Hydroxy Benzoate/0.18 g
"Avicel" RC-591/0.75 g

配制方法:

Dissolve the methyl and propyl p-hydroxy benzoates in 50 ml distilled water using a high speed agitator. Add slowly, with efficient mixing, the "Avicel" RC-591. Mix for at least 30 min or until completely dispersed. Separately dissolve the sucrose in 25 ml warm distilled water. Cool and add to the "Avicel" RC-591 dispersion. Dissolve the sodium citrate in 5 ml distilled water; add to above dispersion; mix well. Add and disperse the three sulfonamides; mix until homogeneous.
Avoid excessive air entrapment. Adjust to volume with distilled water; mix well. If possible, pass through a homogenizer or colloid mill.
Deaerate if necessary.