配方类型:

DRUG PRODUCTS

配方说明:

Children's Aspirin Tablets

配方组成:

Mannitol USP (powdered)/1000 g Per Tablet
Starch/10.6 mg Per Tablet
Sodium Saccharin/7 g Per Tablet
Talc/8.0 mg Per Tablet
Aspirin (20-mesh)/81.0 mg Per Tablet
Stearic Acid/0.3 mg Per Tablet
10% Acacia Sol'n./230.ml Per Tablet
Flavor/q.s. Per Tablet

配制方法:

Granulate the mannitol and saccharin with the acacia solution, dry at 110'F and pass through a 20-mesh screen.
Mix the aspirin with the dried mannitol granulation. Take extreme care to avoid moisture pick-up. Add the flavor to the starch, mixing thoroughly. Add the talc and stearic acid, screened to 100-mesh, to the flavor-starch mixture. Blend this combination of flavoring, starch, talc and stearic acid with the mannitol-aspirin mixture.
Compress using 11/32 in. standard concave punch to a hardness of 4-6 kg (Strong-Cobb-Arner tester).