配方类型:

DRUG PRODUCTS

配方说明:

Tablet Coating

配方组成:

Pan speed (rpm)/16
Coated Tablets
Lake Pigments/7.0
Visc.: Brookfield (cps)/30
"Klucel" LF/6.4
Shellac/-
Ethyl Cellulose/2.2
Lake Pigments/4.9
Methanol/q.s.to 100%
Ethanol/-
Total solids (%)/13.5
Visc.: Brookfield (cps)/350
Visc.: Zahn cup No.3 (s)/33
Spray gun-Binks 46
Spray gun-Binks 41 F/Airless gun
Temp. of air to coating pan (F)/130
Pan speed (rpm)/23
Thickness of coating (mil)/2.2
Visc.: Zahn cup No.3 (s)/9
Disintegration time (min)/2.7
Shellac/1.0
Thickness of coating (mil)/1.5
Disintegration time (min)/1.5
Methanol/-
"Klucel" LF/3.0
Ethyl Cellulose/-
Ethanol/q.s.to 100%
Shellac/-
Ethyl Cellulose/1.0
Lake Pigments/2.2
Methanol/-
Ethanol/q.s.to 100%
"Klucel" LF/3.0
Spray gun-Binks 46/Air gun
Total solids (%)/6.2
Visc.: Brookfield (cps)/40
Visc.: Zahn cup No.3 (s)/10
Spray gun-Binks 46/Air gun
Spray gun-Binks 41 F

配制方法:

Tablets are finished to a high gloss with a finish-coat of clear "Klucel" solution. Application of this coating is made in the coating pan. The clear overcoat is the "Klucel"-shellac or "Klucel"-ethyl cellulose binder solution (used in the color coating operation) to which is added some "Carbowax" 4000 to improve tablet slip. A typical composition is 4.9 parts "Klucel," 1.3 parts shellac solids, 1.0 parts "Carbowax" 4000, and 93.7 parts by weight of ethanol.