配方类型:

DRUG PRODUCTS

配方说明:

Acne Preparations

配方组成:

B: Glycerin/5.00
Prepare Part A by adding the "Veegum" slowly to the water, agitating
continually until smooth. Heat to 75'C. Heat Part B ingredients to 70'C.
Add Part B to A with mixing until smooth. Add Parts C and D with mixing
until cool. Add Part E.
Formula No.4 (Benzoyl Peroxide
Salicylic Acid/3.00
Titanium Dioxide/2.90
Allantoin/0.25
Resorcinol/3.00
"Triton" X-100/0.20
Iron Oxides/0.25
Water/29.70
Water/34.00
C: "Nytal" 300/16.00
Titanium Dioxide/2.90
Iron Oxides/1.10
Sulfur/5.00
Sulfur/5.00
A: "Veegum"/2.0
Water/58.2
"Triton" X-202/0.70
D: "Vancide" 89RE/1.00
B: Propylene Glycol/10.0
"Amerchol" L-101/15.0
"Aldo" MSA/3.0
"Triton" X-202/1.4
C: "A-C" Polyethylene/10.0
D: Eucalyptus Oil/0.4
E: Preservative/q.s.
A: "Promulgen" D/2.5
B: Glycerin/5.00
Water/30.65
"Schercomol" DID/1.5
Water (deionized)/73.2
B: "Avicel" CL-611/2.8
C

配制方法:

The Benzoyl Peroxide grind is prepared in advance by slurrying the BP in polyethylene glycol 400 at ambient temperature, then passing through a colloid mill to desired particle size.
All ingredients of Part A are loaded together in a kettle and heated to 75'C. Simple propeller mixing will form a crude emulsion which is then cooled to 60'C.
Agitation of Part A is now sharply increased to form a vortex, into which Part B ("Avicel" CL-611) is added quickly. After 5 min high-shear agitation of Parts A and B at 60'C, begin slow cooling via moderate agitation to allow escape of entrapped air. Cool to 40'C.
Part C is prepared in a separate kettle, by simply stirring together (via propeller agitation at ambient temp.) the 50% BP grind and the water of Part C.
Part C is then slowly added to the 40'C Parts A and B with moderate propeller agitation. Finished batch should be cooled to 30-35'C before taking off, and if any BP specs are still visible passed through a high pressure homogenizer such as a