配方类型:

DRUG PRODUCTS

配方说明:

Benzoyl Peroxide Acne Cream

配方组成:

B: "Avicel" CL-611/2.8
"Schercomol" DID/1.5
C: Benzoyl Peroxide Grind (50% active in PEG-400)/10.0
Water/10.0
Deionized Water/73.2
A: "Promulgen" D/2.5

配制方法:

Benzoyl Peroxide grind- is prepared in advance by slurrying the BP in Polythylene Glycol 400 at ambient temperature, then passing through a colloid mill to desired particle size.
All ingredients in Part A are loaded together in a kettle and heated to 75'C. Simple propellor mixing will form a crude emulsion which is then cooled to 60'C.
Agitation of Part A is now sharply increased, to form a vortex, into which Part B ("Avicel" CL-611) is added quickly. After 5 min high-shear agitation of Parts A and B at 60'C, begin slow cooling via moderate agitation to allow escape of entrapped air. Cool to 40'C.
Part C is prepared in a separate kettle, by simply stirring together (via propellor agitation at ambient temp.) the 50% BP grind and the Part C water.
Part C is then slowly added to the 40'C Parts A and B, with moderate propellor agitation. Finished batch should be cooled to 30-35'C before taking off, and if any BP specs are still visible passed through a high pressure homogenizer such as a Gauli