配方类型:

DRUGS

配方说明:

配方组成:

colloidal silica/0.2
microcrystalline cellulose/22.5
magnesium stearate/0.5
prednisone (micronezed)/--
tablte wt./200 mg
reoative wt. standard deviation/0.60%
dicalcium phosphate ditydrate/--
ejection force/250 N
crushing strength (schleuniger)/7.9 kg
friabililty (roche, 100 rotations)/0.4%
disintegrating time (USP XIX)/20 s
disintegrating time (without using discs)/21 s
lactose (extra fine crystalline)/49.3
phenobaritone/25.0
phenobarbitone 50 mg
"primojel"/2.5

配制方法:

prepare by direct compression using an instrumented single punch tableting machine at a compression force of 20 kN. tablet diameter: 7 mm for the prednisone tablets and 9 mm for the phenobarbitone tablets.
after storage of the tablets at extreme humid conditions, 8 weeks 20 C and 85% relative bumidity, the disintegration time was 20 s for the prednisone tablets and 29 s for the phenobarbitone tablets.