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A solution of 2-bromophenol (17.3 g, 100 mmol) in 50 mL of H2O was added NaOH (8 g, 200 mmol), 3-bromopropanoic acid (15.3 g, 100 mmol), and the mixture was stirred at reflux overnight. The reaction solution was diluted with H2O, extracted with EtOAc. The aqueous layer was acidified to pH=1˜2 and extracted with EtOAc. The combined organic phase was washed with brine, dried over anhydrous Na2SO4 and concentrated to afford 3-(2-bromophenoxy)propanoic acid.
| 产品 | |
| 反应物 |
o-bromo-phenol sodium hydroxide 3-bromopropionic acid |
| 试剂 |
water water |
| 程序 |
1、Add A solution of 2-bromophenol (17.3 g, 100 mmol) in 50 mL of H2O was added NaOH (8 g, 200 mmol), 3-bromopropanoic acid (15.3 g, 100 mmol) 2、Stir the mixture was stirred 3、Heat at reflux overnight 4、Add The reaction solution was diluted with H2O 5、Extract extracted with EtOAc 6、Extract extracted with EtOAc 7、Wash The combined organic phase was washed with brine 8、Dry dried over anhydrous Na2SO4 9、Concentrate concentrated 10、Yield to afford 3-(2-bromophenoxy)propanoic acid |
角色：product
分类：产品
实体类型：exact
角色：reactant
分类：原料
实体类型：exact
角色：reactant
分类：原料
实体类型：exact
角色：reactant
分类：原料
实体类型：exact
角色：solvent
分类：催化剂
实体类型：exact
角色：solvent
分类：催化剂
实体类型：exact